WDR5

2CNX, 2CO0, 2G99, 2G9A, 2GNQ, 2H13, 2H14, 2H68, 2H6K, 2H6N, 2H6Q, 2H9L, 2H9M, 2H9N, 2H9P, 2O9K, 3EG6, 3EMH, 3MXX, 3N0D, 3N0E, 3P4F, 3PSL, 3SMR, 3UR4, 3UVK, 3UVL, 3UVM, 3UVN, 3UVO, 4A7J, 4CY1, 4CY2, 4ERQ, 4ERY, 4ERZ, 4ES0, 4ESG, 4EWR, 4GM3, 4GM8, 4GM9, 4GMB, 4IA9, 4O45, 4QL1, 4Y7R, 5EAL, 5EAP, 5EAR, 4QQE, 5EAM11091140858ENSG00000196363ENSMUSG00000026917P61964P61965NM_017588NM_052821NM_080848NP_060058NP_438172NP_543124WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.2cnx: WDR5 AND HISTONE H3 LYSINE 4 DIMETHYL COMPLEX AT 2.1 ANGSTROM2co0: WDR5 AND UNMODIFIED HISTONE H3 COMPLEX AT 2.25 ANGSTROM2g99: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR52g9a: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR52gnq: Structure of wdr52h13: Crystal structure of WDR5/histone H3 complex2h14: Crystal of WDR5 (apo-form)2h68: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex2h6k: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex2h6n: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex2h6q: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex2h9l: WDR5delta232h9m: WDR5 in complex with unmodified H3K4 peptide2h9n: WDR5 in complex with monomethylated H3K4 peptide2h9p: WDR5 in complex with trimethylated H3K4 peptide2o9k: WDR5 in Complex with Dimethylated H3K4 Peptide WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. WDR5 has been shown to interact with Host cell factor C1 and MLL. It also interacts with the long non-coding RNA HOTTIP.WDR5 is a key determinant for MYC recruitment to chromatin