I carbamoylmethylamino acetic acid derivatives substituted as new inhibitors of NEP

A compound of formula (III): wherein: X1 is OH, -O-C1-7alkyl, -NRaRb, -NHS (O) 2-C1-7 alkyl or -NHS (O) 2-benzyl, wherein R and Rb for each occurrence are independently H or C1-7 alkyl; R1 is C1-6 alkyl or C6-10-aryl-C1-6 alkyl, wherein alkyl is optionally substituted with benzyloxy, hydroxy or C1- 6 alkoxy; for each occurrence R2 is independently C1-6-alkoxy, hydroxy, halo, C1-6-alkyl, cyano or trifluoromethyl; R4 and R5 are independently H or C1-6 alkyl; A1 is a bond or C1-3 alkylene chain; R3 is an unsubstituted 5- or 6- membered, C6-10 aryl or C3-7-cycloalkyl, wherein each heteroaryl, aryl or cycloalkyl are optionally substituted with one or more groups independently selected from the group consisting of C1-6 alkyl, halo, halo C1-6 alkyl, C1-6 alkoxy, hydroxy, CO2H and CO2C1-6 alkyl; R6 for each occurrence is independently halo, hydroxy, C1-C7 alkoxy, halo, C1-7 alkyl or halo-C1-7 alkyl; or R4, A1-R3 together with the nitrogen to which R4 and A1-R3 are attached form a heterocyclyl 4- to 7-membered heteroaryl or 5- to 6-membered of each of which is optionally substituted with one or more groups independently selected from the group consisting of C1-6 alkyl, halo, halo C1-6 alkyl, C1-6 alkoxy, hydroxy, CO2H and CO2C1-6 alkyl; m is 0 or an integer of 1 to 5; s is 0 to an integer of 1 to 4; X2 is halo; p is 0 or an integer of 1 to 4; or a pharmaceutically acceptable salt thereof.