Two Ni(II)-Based Coordination Complexes: Crystal Structures and Treatment Activity on Neonatal Hypoxic-Ischemic Encephalopathy

Two novel metal–organic coordination complexes based on L [L = 3,6-bis(imidazol-1-yl)pyridazine], which could also be called as [Ni(L)(1,3,5-H2BTC)2H2O]n 1 (1,3,5-H3BTC = 1,3,5-benzenetricarboxylic acid) and {[Ni2(L)(2,6-PYDC)2(H2O)2]·5H2O}n 2 (2,6-H2PYDC = 2,6-pyridine dicarboxylic acid) have been formed using solvothermal method by reaction of Ni(II) salts with the L ligand in the presence of different carboxylate ligands (1,3,5-H3BTC for 1 and 2,6-H2PYDC for 2). The treatment activity of compounds 1 and 2 on the neonatal hypoxic-ischemic encephalopathy was estimated, then the relevant mechanism was discussed. Firstly, the quantity of the tumor necrosis factor-α (TNF-α) and neuron-specific enolase (NSE) in the cerebrospinal fluid was measured by enzyme linked immunosorbent assay (ELISA) detection kit. In addition to this, the expression levels of the glutamate receptor on the brain nerve cells were estimated by real time reverse transcription-polymerase chain reaction (RT-PCR).