Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment

Britta Will,Thomas O. Vogler,Boris Bartholdy,Francine E. Garrett-Bakelman,Jillian Mayer,Laura Barreyro,Ashley Pandolfi,Tihomira I. Todorova,Ujunwa C. Okoye-Okafor,Robert F. Stanley,Tushar D. Bhagat,Amit Verma,Maria E. Figueroa,Ari Melnick,Michael Roth,Ulrich Steidl

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment

2013

Britta Will
Thomas O. Vogler
Boris Bartholdy
Francine E. Garrett-Bakelman
Jillian Mayer
Laura Barreyro
Ashley Pandolfi
Tihomira I. Todorova
Ujunwa C. Okoye-Okafor
Robert F. Stanley
Tushar D. Bhagat
Amit Verma
Maria E. Figueroa
Ari Melnick
Michael Roth
Ulrich Steidl

How hematopoietic stem cells coordinate self-renewal and differentiation remains unclear. Steidl and colleagues show that the transcription factor and chromatin remodeler Satb1 is required for their self-renewal.

Keywords:

Immunology
Transcription factor
Cell biology
Cellular differentiation
SATB1
Stem cell
Haematopoiesis
Cell polarity
Chromatin
Proto-Oncogene Proteins c-myc
Biology

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