Germline variant alleles in rs12422149 of SLCO2B1 and response to abiraterone acetate (AA) in men with metastatic castration-resistant prostate cancer (mCRPC).

Andrew W. Hahn,David Gill,Peter Hale,Austin Poole,Roberto Nussenzveig,Sara Wilson,James M. Farnham,Robert A. Stephenson,Benjamin L. Maughan,Lisa A. Cannon-Albright,Neeraj Agarwal

Germline variant alleles in rs12422149 of SLCO2B1 and response to abiraterone acetate (AA) in men with metastatic castration-resistant prostate cancer (mCRPC).

2018

Andrew W. Hahn
David Gill
Peter Hale
Austin Poole
Roberto Nussenzveig
Sara Wilson
James M. Farnham
Robert A. Stephenson
Benjamin L. Maughan
Lisa A. Cannon-Albright
Neeraj Agarwal

5076Background: Predictive biomarkers of response to AA in advanced prostate cancer are needed. SLCO2B1 encodes a protein that mediates transport of AA into tissue. A pre-clinical study showed that...

Keywords:

Abiraterone acetate
Germline
Prostate cancer
Pathology
Castration
Cancer research
Allele
Medicine
predictive biomarker
a protein
variant allele
castration resistant

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