3'-Demethoxy-3'-hydroxystaurosporine, a novel staurosporine analogue produced by a blocked mutant.
1995
3'-Demethoxy-3'-hydroxystaurosporine, 1 (CGP 58 546), a novel Staurosporine analogue, was isolated from a mutant of Streptomyces longisporoflavus R19 blocked in the last step of the biosynthetic pathway. CGP 58 546 was less potent than Staurosporine, but it showed a more selective inhibition pattern against various subtypes of protein kinase C.
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KQI