Mechanisms of imidazoline I2 receptor agonist‐induced antinociception in rats: involvement of monoaminergic neurotransmission

Background and Purpose Although the antinociceptive efficacies of imidazoline I2 receptor agonists have been established, the exact post‐receptor mechanisms remain unknown. This study tested the hypothesis that monoaminergic transmission is critical for I2 receptor agonist‐induced antinociception.