Preparation and Properties of Oligomeric Sulfonated Chitosan

In the homogeneous system, the low molecular weight Chitosan is obtained by H2O2 oxidation degradation method. Acetyl Sulface reacted by the mixture of Acetic Anhydride and Concentrated Sulfuric Acid at equal proportion is the reagent. low molecular weight Chitosan being as raw materials, Vulcanized Oligomer Chitosan is sulfonated with good water-solubility and high sulfur content under certain conditions. It has been tested for the influence of the usage of sulfonated reagent, reaction temperature and reaction time on Sulfer content. The best condition for preparation Vulcanized Oligomer Chitosan is 5ml of Acetyl Sulface with the reaction temperature of 25°C and time of 5 Hours. It’s a new potential heparin with around 100 nm particale size tested by spectral analysis and SEM measurements, which could be a new reagent in other fields.