Meta-analysis of wavefront-guided vs. wavefront-optimized LASIK for myopia.

PURPOSE: To detect possible differences in clinical outcomes between wavefront-guided laser in situ keratomileusis (LASIK) and wavefront-optimized LASIK for the treatment of myopia. METHODS: A comprehensive literature search of Cochrane Library, MEDLINE, and EMBASE to identify relevant trials comparing LASIK with wavefront-guided and wavefront-optimized. A meta-analysis was performed on the results of the reports. Statistical analysis was performed using RevMan 5.0 software. RESULTS: Seven articles describing a total of 930 eyes were identified. There were no statistically significant differences in the final proportion of eyes achieving uncorrected distance visual acuity of 20/20 or better [odds ratio, 1.04; 95% confidence interval (CI), 0.66 to 1.65; p = 0.86], manifest refractive spherical equivalent within ± 0.50 D of the target (odds ratio, 0.96; 95% CI, 0.53 to 1.75; p = 0.90). No patient lost ≥ 2 lines of distance-corrected visual acuity at posttreatment. The changes in higher order aberrations were not statistically significant different between the two groups with preoperative root-mean-square (RMS) higher order aberrations 0.3 μm (weighted mean difference, -0.10; 95% CI, -0.15 to -0.06; p 0.3 μm.