Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

Cecilia Bottecchia,François Lévesque,Jonathan P. McMullen,Yining Ji,Mikhail Reibarkh,Feng Peng,Lushi Tan,Glenn Spencer,Jarod Nappi,Dan Lehnherr,Karthik Narsimhan,Michael K. Wismer,Like Chen,Yipeng Lin,Stephen M. Dalby

Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

2021

Cecilia Bottecchia
François Lévesque
Jonathan P. McMullen
Yining Ji
Mikhail Reibarkh
Feng Peng
Lushi Tan
Glenn Spencer
Jarod Nappi
Dan Lehnherr
Karthik Narsimhan
Michael K. Wismer
Like Chen
Yipeng Lin
Stephen M. Dalby

We report the development and scale-up of a continuous flow photochemical benzylic bromination en route to belzutifan (MK-6482), a small molecule for the treatment of renal cell carcinoma associate...

Keywords:

manufacturing process
Photochemistry
Visible spectrum
continuous flow
Halogenation
Materials science

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