Synthesis of (+)‐O‐Methylthalibrine by Employing a Stereocontrolled Bischler—Napieralski Reaction and an Electrochemically Generated Diaryl Ether.

An efficient electrochemical four-step route was developed for the preparation of diaryl ether derivatives by using halogenation and dehalogenation processes in addition to electrochemical phenolic oxidation and reduction reactions. The synthesis of (+)-O-methylthalibrine was achieved by employing this strategy along with a stereoselective Bischler–Napieralski reaction.