Successful treatment of POEMS syndrome in a young male with stem cell transplantation

POEMs syndrome is a rare paraneoplastic disorder related to plasma cell dyscrasia. The present study deals with an unusual case of POEMs syndrome in a young male who came with ascending demyelinating polyneuropathy, resulting in complete quadriparesis. The diagnosis was based on clinical findings of gynecomastia, hyperpigmentation and hypertrichosis of skin and lymphadenitis. Detailed laboratory investigations and imaging confirmed POEMS syndrome. In view of the rapidly progressing polyneuropathy, the patient was treated with chemotherapy followed by stem cell transplantation. The patient recovered completely after the treatment.