p<0.05 Is Not Enough

The p-value has been treated as a benchmark of reliability for an experimental output in biology. In biological research, results with p≤0.05 are conventionally regarded as statistically significant. However, a criticism is currently being emerged claiming that statistical significance in biology has now become very fragile. Simultaneously, proposals for review of statistical inference based on p-value<0.05 are surfacing as alternate strategy of statistical significance. The present review discusses emerging issues related to p-value<0.05 in biological research and some possible ways to address such issues.