Biodegradable Nanoparticles: A Recent Approach and Applications.

Biodegradable nanoparticles (NPs)are the novel carriers for the administration of drug molecules. Biodegradable nanoparticles have become popular recently because of their special features such as targeted delivery of drugs; improve bioavailability and better therapeutic effectiveness of embedded drug's ability to administer the drug at a constant rate. Polymeric NPs are very small-sized polymeric colloidal elements in which a drug of interest may be encapsulated or incorporated in their polymeric network or conjugated or adsorbed on the layer. Various polymers are employed in the manufacturing of nanoparticles, some of the frequently employed polymers are agents, Chitosan, cellulose, gelatin, gliadin, polylactic acid, polylactic-co-glycolic acid, and pullulan. Nanoparticles are progressively explored for delivery of targeted ARVs to cells of HIV-infected and show accomplish the prolonged kinetic release. Drug embedded in this system can give better effectiveness, diminished resistance of drugs, the reduction in systemic toxicity and symptoms, also enhanced patient compliance. The present review highlights the frequently employed manufacturing methods for biodegradable nanoparticles, various polymers used, and its application in anti-retroviral therapy. Also, common evaluation parameters to check the purity of nanoparticles, ongoing and recently concluded clinical trials and patents filled by the various researchers and the future implication of biodegradable NPs in an innovative drug delivery system are described. The biodegradable NPs are promising systems for administration of a broad variety of drugs including anti-retroviral drugs and hence biodegradable nanoparticles can be employed in the future for the treatment of several diseases and disorders.