Carcinogenic activity of synthetic chrysotile asbestos with various fiber sizes and chemical composition

: Synthetic Mg-chrysotiles (analogous to natural ones by chemical composition) with fine short, thick short and fine long fibres under intrapleural injections (20 mg thrice) induced mesotheliomas in noninbred rats in 3.3, 0 and 12% of rats, respectively. Ni- and Co-chrysotiles with fine and short fibres caused such tumours in 7.6 and 30.2%, Co-chrysotile with plate-like fibres induced tumours in 26.8%. The role of chemical structure and particle sizes have been discussed.