Multimodal Analysis of Hyperautofluorescent Ring Size in Retinitis Pigmentosa

BACKGROUND AND OBJECTIVE: To determine if a correlation exists between hyperautofluorescent ring size with visual acuity (VA), foveal avascular zone (FAZ) size, and retinal capillary perfusion density (CPD) in retinitis pigmentosa (RP). PATIENTS AND METHODS: Eighteen eyes from nine patients with RP were imaged using fundus autofluorescence (AF) to identify autofluorescence defects, and hyperautofluorescent ring size was measured with an image-processing program. Spectral-domain optical coherence tomography angiography was used to measure FAZ area and calculate parafoveal CPD in the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) using both a 3 mm × 3 mm and 6 mm × 6 mm strategy. RESULTS: The area of hyperautofluorescence was not strongly correlated with SCP perfusion density (P = .74), DCP perfusion density (P = .25), FAZ area (P = .14), or VA (P = .33). CONCLUSION: The area of the hyperautofluorescent ring does not correlate with VA, retinal CPD, or FAZ area. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:492-496.].