Platelet Recovery Prior to Stem Cell Transplantation Predicts for Post- Transplant Outcomes in Patients with AML

Achievement of complete remission (CR), with 100K/ml remains the gold standard achievement of chemotherapy for AML. A significant fraction of patients proceed to HSCT with 100K/ml (CRp). It is possible that with new AML therapies, the proportion of patients in such a situation will increase. We hypothesized that achievement of CRp has a worse prognostic connotation than ‘classically’ defined CR, and sought to investigate this hypothesis in a cohort of AML patients transplanted between 7/1995 to 12/2007 at our institution (N=427). Methods: Patients were eligible for this analysis if they were in the following disease status at transplantation: compete remission (CR); first CR (CR1; 100K/ml); second CR (CR2); first CRp (CRp1): patients that had 5% and no platelet recovery); CRp2: patients that after first relapse achieved Results: Median age was 50 years (range 6–74); 51% of patients were 50 years or older (n=218); 55% were male (n=236). Disease status at HSCT was CR1 in 38% (n=164), CR2 in 24% (n=102), CRp1 in 11% (n=48), CRp2 in 7% (n=30); PIF 11% (n=47), and rel1 8% (n=36). Cytogenetics data were available for 90% (n=386) of patients. The proportion of poor-risk cytogenetics was comparable in patients who were in CR1 (39%) and CRp1 (44%), p=0.3, and in patients who were in CR2 (15%) and CRp2 (24%) p=0.2. Source of stem cells was BM in 41% of patients (n=174) and peripheral blood in 59% of patients (n=253). Ninety-six percent of patients engrafted. Fifty-one percent of patients have died (n=219); actuarial survival at 36-months was 49% for all patients. Thirty-one percent of patients (n=134) have progressed. Median follow-up among survivors is 42 months (range 3–131months). Non-relapse mortality (NRM) (figure 1), overall survival (OS) (figure 2), and hazard ratios for OS and NRM at 1-year (Table) favored patients who were transplanted in CR1 (vs. patients in CRp1 or PIF), or in CR2 (vs. CRp2 or rel1). Conclusion: In this cohort of patient with AML and MDS, patients in CR (CR1 or CR2) demonstrated significantly better OS and NRM compared to patients who underwent HSCT in CRp (CRp1 or CRp2). CRp conferred an intermediate prognostic status, better than refractory disease, but significantly worse than ‘classic’ CR. Our results suggest that achieving a CR prior to HSCT should remain the gold standard for patient in AML or MDS receiving allogeneic HSCT. Table. Hazard Ratios (HR) for non-relapse mortality (NRM) and overall survival (OS) at 1 year.