Fast Label-free Photoacoustic Microscopy

Photoacoustic microscopy (PAM) is an emerging hybrid imaging modality which maps superior optical contrast acoustically through the photoacoustic effect. Compared with pure optical microscopic imaging modalities, PAM employs absorption contrast rather than scattering contrast, which showed capability for exploring anatomical, functional, and molecular information in biological tissues without exogenous agents. Here, we present fast label-free photoacoustic microscopy, successfully reconstructing the microvasculature in a mouse ear and histopathological features in a mouse uterus.