Preparation and Properties Characterization of Modified Chitosan Composited Hemostatic Materials

Carboxymethyl chitosan (CAS) was obtained by carboxymethylation of chitosan (CS).The Ag+-CAS,TiO2-CAS and Ag+-TiO2-CAS were prepared by introducing AgNO3 and nanometre TiO2 solution into the product obtained the previous step. The structures of samples were characterized by IR, XRD, SEM etc. The properties of cruor and hemostasis were studied by biological experiment. The results showed that there were characteristic absorption peaks of carboxymethyl chitosan sodium salt around 3423cm-1 and 1380cm-1 in the IR spectra of modified carboxymethyl chitosan. The XRD showed it was metals Crystalline. The average diameter of CAS was about 14.8nm, the Ag+ was 143.5nm, nanometre TiO2 was 267.2nm and all of them were homodisperse. The properties of crour and hemostasis of Ag+-TiO2-CAS were superior to Ag+-CAS and TiO2-CAS, while the Ag+-CAS and TiO2-CAS were also have an advantage over CAS.