Postoperative changes of serum proteins and immune response in critical patients and the effects of recombinant human growth hormone

Objective To investigate the postoperative changes of serum proteins and immune responses in critical patients and the effect of recombinant human growth hormone(rhGH).Method 45 critical patients were divided randomly into rhGH group (15 cases) and control group (30 cases) after operation. Patients in rhGH group were given rhGH 8*!U/d,im for 7 days starting 48 hours post operation. Result The postoperative level of serum transferin,albumin and prealbumin decreased in all patients, and so did the activity of CD 3,CD 4 ,CD 8,NK and the ratio of CD 4/CD 8 .Serum prealbumin level increased significantly in rhGH group at day 4 and after ( P 0 05);The level of serum prealbumin,transferin and albumin increased significantly in rhGH group at day 8 and after( P 0 05, P 0 01, P 0 05), and so did the activity of CD 4,NK and the ratio of CD 4/CD 8 ( P 0 01, P 0 01 , P 0 05).Conclusion The combination of nutrition support with rhGH improves the nutritional status and immume response rapidly in critical surgical patients.