Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.

Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which mediates several biological functions, including cell growth, differentiation,