The role of Vδ2-negative γδ T cells during cytomegalovirusreactivation in recipients of allogeneic stem celltransplantation

Reactivation of cytomegalovirus (CMV) remains a serious complication after allogeneic stem cell transplantation, but the role of gamma-delta T cells is undefined. We have studied the immune reconstitution of Vdelta2negative (Vdelta2neg) gamma-delta T cells, including Vdelta1 and Vdelta3 subsets and Vdelta2positive (Vdelta2pos) gamma-delta T cells in 40 patients during the first 24 months after stem cell transplantation. Our study shows new evidence for role of gamma-delta T cells in the immune response to CMV reactivation in transplantation recipients.