The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Paul J. Emmerson,Feng Wang,Yong Du,Qian Liu,Richard Todd Pickard,Malgorzata D Gonciarz,Tamer Coskun,Matthew J Hamang,Dana Sindelar,Kimberly K Ballman,Lisa A Foltz,Avinash Muppidi,Jorge Alsina-Fernandez,Gavin C Barnard,Jason X Tang,Xilin Liu,Xudong Mao,Robert W. Siegel,John H Sloan,Pamela J. Mitchell,Bei B Zhang,Ruth E. Gimeno,Bei Shan,Xinle Wu

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

2017

GDF15 has potent anti-obesity effects, but its receptor was previously unknown. GFRAL has now been identified as the receptor for GDF15, and it mediates the effects of GDF15 via central actions in the hindbrain.

Keywords:

Neuron-derived orphan receptor 1
Orphan receptor
Estrogen-related receptor alpha
Hindbrain
Immunology
ROR1
Medicine
5-HT5A receptor
Receptor
Estrogen-related receptor gamma
GDF15
Endocrinology
Internal medicine

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

238

Citations