Estrogen-related receptor gamma

Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene. It behaves as a constitutive activator of transcription.1KV6, 1TFC, 1VJB, 2E2R, 2EWP, 2GP7, 2GPO, 2GPP, 2GPU, 2GPV, 2P7A, 2P7G, 2P7Z, 2ZAS, 2ZBS, 2ZKC210426381ENSG00000196482ENSMUSG00000026610P62508P62509NM_001243510NM_001243511NM_001243512NM_001243513NM_001243514NM_001243515NM_001243518NM_001243519NM_001438NM_206594NM_206595NM_001350122NM_001350123NM_001350124NM_001350125NM_001243792NM_011935NM_001357534NM_001357535NM_001357536NP_001230439NP_001230440NP_001230441NP_001230442NP_001230443NP_001230444NP_001230447NP_001230448NP_001429NP_996317NP_996318NP_001337051NP_001337052NP_001337053NP_001337054NP_001230721NP_036065NP_001344463NP_001344464NP_001344465There is evidence that bisphenol A functions as an endocrine disruptor by binding strongly to ERR-γ. BPA as well as its nitrated and chlorinated metabolites seems to binds strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER)., BPA binding to ERR-γ preserves its basal constitutive activity. It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.