The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer

Hiroko Natsume,Kazuya Shinmura,Hong Tao,Hisaki Igarashi,Masaya Suzuki,Kiyoko Nagura,Masanori Goto,Hidetaka Yamada,Matsuyoshi Maeda,Hiroyuki Konno,Satoki Nakamura,Haruhiko Sugimura

The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer

2012

Hiroko Natsume
Kazuya Shinmura
Hong Tao
Hisaki Igarashi
Masaya Suzuki
Kiyoko Nagura
Masanori Goto
Hidetaka Yamada
Matsuyoshi Maeda
Hiroyuki Konno
Satoki Nakamura
Haruhiko Sugimura

Background Genomic DNA amplification is a genetic factor involved in cancer, and some oncogenes, such as ERBB2, are highly amplified in gastric cancer. We searched for the possible amplification of other genes in gastric cancer.

Keywords:

Signal transducing adaptor protein
genomic DNA
Gene dosage
Nuclear protein
Cancer
Gene
CRKL
Biology
Molecular biology
Gene duplication

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