CRKL

2BZX, 2BZY, 2EO3, 2LQN, 2LQW139912929ENSG00000099942ENSMUSG00000006134P46109P47941NM_005207NM_001277231NM_007764NP_005198NP_001264160NP_031790Crk-like protein is a protein that in humans is encoded by the CRKL gene.2bzx: ATOMIC MODEL OF CRKL-SH3C MONOMER2bzy: DIMERIC OF CRKL-SH3C DOMAIN2dbk: Solution structures of the SH3 domain of human Crk-like protein Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1. CRKL has been shown to interact with: