Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

Tamjeed Saleh,Wojciech Jankowski,Ganapathy Sriram,Paolo Rossi,Shreyas Shah,Ki-Bum Lee,Lissette A. Cruz,Alexis J. Rodriguez,Raymond B. Birge,Charalampos G. Kalodimos

Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

2016

Tamjeed Saleh
Wojciech Jankowski
Ganapathy Sriram
Paolo Rossi
Shreyas Shah
Ki-Bum Lee
Lissette A. Cruz
Alexis J. Rodriguez
Raymond B. Birge
Charalampos G. Kalodimos

Cyclophilin A binds a proline motif in human CrkII, preventing phosphorylation by Abl and EGFR. Decreased CrkII phosphorylation ensures interactions with the focal adhesion proteins paxillin and p130CAS to stimulate cellular migration.

Keywords:

Molecular biology
Biology
ABL
Paxillin
Cyclophilin A
Phosphorylation
Cell biology
Adapter molecule crk
Cancer research
Signal transduction
Oncogene Proteins v-abl
Focal adhesion
Cypa
Signal transducing adaptor protein

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