Adapter molecule crk

1JU5, 2DVJ, 2EYV, 2EYW, 2EYX, 2EYY, 2EYZ, 2MS4139812928ENSG00000167193ENSMUSG00000017776P46108Q64010NM_016823NM_005206NM_001277219NM_001277221NM_133656NP_005197NP_058431NP_001264148NP_001264150NP_598417Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.1b07: CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR1cka: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK1ckb: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK1ju5: Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy1m30: Solution structure of N-terminal SH3 domain from oncogene protein c-Crk1m3a: Solution structure of a circular form of the truncated N-terminal SH3 domain from oncogene protein c-Crk.1m3b: Solution structure of a circular form of the N-terminal SH3 domain (A134C, E135G, R191G mutant) from oncogene protein c-Crk.1m3c: Solution structure of a circular form of the N-terminal SH3 domain (E132C, E133G, R191G mutant) from oncogene protein c-Crk2dvj: phosphorylated Crk-II2eyv: SH2 domain of CT10-Regulated Kinase2eyw: N-terminal SH3 domain of CT10-Regulated Kinase2eyx: C-Terminal SH3 domain of CT10-Regulated Kinase2eyy: CT10-Regulated Kinase isoform I2eyz: CT10-Regulated Kinase isoform II2ggr: Solution structure of the C-terminal SH3 domain of c-CrkII Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. The CRK protein participates in the Reelin signaling cascade downstream of DAB1. Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1. v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral 'gag' protein with the SH2 and SH3 domains of cellular Crk. The name Crk is from 'CT10 Regulator of Kinase' where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells. Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase. CRK (gene) has been shown to interact with: