The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1
2009
The glycolytic enzyme Pfkfb3 is shown to be constitutively ubiquitylated by the APC/C ligase and degraded in neurons. These findings might explain the lower glycolytic metabolism in these cells relative to astrocytes.
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