Nanodesigning of multifunctional quantum dots and nanoparticles for the treatment of fibrosarcoma.

AIM An effective, dual drug(DD) loaded nanocarrier system (nano particle(NP), quantum dots(QDs)) having two active substances was aimed to develop for the treatment of fibrosarcoma. METHODS Zinc oxide(ZnO) QDs were produced using zinc acetate dehydrate as a precursor, were incorporated with chitosan(Ch), and finally decorated with PEG-linked folic acid and were found to be effective after imatinib mesylate(IM) and dexketoprofen trometamol(DT) were loaded. Characterizations, invitro drug releases, cell toxicities, penetrations through cell lines and in-vivo animal tests of the prepared nanosystems were performed. RESULTS The size of hybrid nanoparticles were 168.6 ± 48.8nm, surface charge was -35.8 ± 0.26mV. The encapsulation efficiency was 75% for IM and 99% for DT. DD-functionalized QDChNPs and lyophilized functionalized QDChNPs in capsules slowed down tumor growth by up to 76.5 % and 88.7 %. CONCLUSIONS Our results demonstrate that developed hybrid nanoparticles are highly effective. This hybrid system gathers many of the advantages of nanotechnology into one form.