Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression

Heidi Anderson,Taylor C. Patch,Pavankumar N. G. Reddy,Elliott J. Hagedorn,Peter Geon Kim,Kathleen A. Soltis,Michael J. Chen,Owen J. Tamplin,Maike Frye,Glenn A. MacLean,Kathleen Hübner,Daniel E. Bauer,John P. Kanki,Guillaume Vogin,Nicholas C. Huston,Minh Nguyen,Yuko Fujiwara,Barry H. Paw,Dietmar Vestweber,Leonard I. Zon,Stuart H. Orkin,George Q. Daley,Dhvanit I. Shah

Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression

2015

Rare endothelial cells in the aorta-gonad-mesonephros (AGM) transition into hematopoietic stem cells (HSCs) during embryonic development. Lineage tracing experiments indicate that HSCs emerge from cadherin 5 (Cdh5; vascular endothelial–cadherin)+ endothelial precursors, and isolated populations of

Keywords:

Endothelial stem cell
Cellular differentiation
Zebrafish
Cadherin
Stem cell
Haematopoiesis
Cell biology
Immunology
Flow cytometry
Biology
Hemangioblast
Transplantation
Endothelium

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