Objective quantification of posterior capsule opacification after cataract surgery, with optical coherence tomography.

RESULTS. Intraoperator reliability was 0.59 and 0.97 for average PI and PCT, respectively. The interoperator concordance correlation coefficient was 0.70 and 0.82 for average PI and PCT, respectively. Median (interquartile range) intensities of the reflectivity spike were 16.88 (dB) (range, 12.88‐20.41) and 11.9 (8.58‐14.28), respectively, in the PCO and control eyes (P 0.001). PCT was found in PCO eyes (median: 86.13 m; range, 46.33‐115.33), whereas no second spike appeared in control eyes (P 0.001). The area under the receiver operating characteristic curve of the average PCT for differentiating pearl-type from fibrosis-type PCO was 0.87 (P 0.001). For a cutoff point of 55.3 m, the sensitivity was 97.5%, and the specificity was 69%. Worse VA correlated significantly only with larger PCT (ro 0.66; P 0.01). CONCLUSIONS. OCT-1 appears useful to quantitate PCO. In addition, this system seems to discriminate between different types of PCO. PCT may be a previously unrecognized factor in VA degradation. (Invest Ophthalmol Vis Sci. 2005;46:3999‐4006)