Mitogen-activated protein kinases activated by lipopolysaccharide and β-amyloid in cultured rat microglia

TO test whether mitogen-activated protein kinases (MAPKs) are involved in microglial activation, pure microglia prepared from 1- to 3-day-old rat brains were activated with either 10 0 ng/ml lipopolysaccharide (LPS) or 5 nM synthetic β-amyloid (Aβ) (25-35). The patterns of MAPK activation following