Acute pancreatitis induced by cyclosporine a following allogeneic hematopoietic stem cell transplant

Pancreatitis has not been reported in allogeneic stem cell transplant(allo-SCT)recipients with cyclosporine in China.This article presented a case of acute pancreatitis in a 49-year-old patient with AML-M2a who received allogeneic stem cell transplant from her HLA identical sister.The preparative regimen consisted of busulfan and cyclophosphamide.The cyclosporine A,short-term methotrexate and antilymphocyte globulin(ATG),were used to prevent the graft-versus-host disease(GVHD).Clinical and laboratory signs of acute pancreatitis were found in the patient on day 20 post-transplant.A diagnosis of acute pancreatitis was made although the pancreas was apparently normal at abdominal contrast-enhanced tomography and ultrasonography.She recovered with supportive care and reduction of cyclosporine dose.In conclusion,cyclosporine is the probable cause of pancreatitis in this patient.