The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

Rajesh Ravindran,Jens Loebbermann,Helder I. Nakaya,Nooruddin Khan,Hualing Ma,Leonardo Gama,Deepa Machiah,Benton Lawson,Paul Hakimpour,Yi-chong Wang,Shuzhao Li,Prachi Sharma,Randal J. Kaufman,Jennifer S. Martinez,Bali Pulendran

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

2016

Rajesh Ravindran
Jens Loebbermann
Helder I. Nakaya
Nooruddin Khan
Hualing Ma
Leonardo Gama
Deepa Machiah
Benton Lawson
Paul Hakimpour
Yi-chong Wang
Shuzhao Li
Prachi Sharma
Randal J. Kaufman
Jennifer S. Martinez
Bali Pulendran

The GCN2 kinase is shown to have a protective role in the regulation of intestinal inflammation during amino acid starvation in a mouse model of colitis.

Keywords:

Inflammation
Autophagy
Cell biology
Autophagy-Related Protein 7
Mucosal immunology
Colitis
Amino acid
Inflammasome
Biochemistry
Kinase
Biology
intestinal mucosa
Protein kinase A
Integrated stress response
Antigen-presenting cell
ATG5

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