Stereocontrolled Nucleophilic Fluorination at the Tertiary sp3-Carbon Center for Enantiopure Synthesis of 3-Fluorooxindoles
2018
The first asymmetric nucleophilic fluorination at the sp3-tertiary carbon center has been developed using inexpensive tetrabutylammonium fluoride (TBAF) without any metal/catalyst for the synthesis of 3-fluoro-3-substituted oxindoles with excellent enantioselectivity (ee up to >99%). Regio- and stereocontrolled ring opening of spiroaziridine with retention of configuration and other experiments revealed that the fluorination proceeded through an anchimeric assistance.
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