Epileptic seizures in a bistable regime

Abnormal synchronisation has been associated with epileptic seizures, one of the most common brain disease. Due to this fact, a better understanding of neuronal synchronisation mechanisms can help in the epilepsy treatment. We study neuronal synchronisation by means of a randomly network with excitatory and inhibitory synapses, where the neuron model is given by the adaptive exponential integrate-and-fire. In our network, we verify that the decrease in the influence of inhibition can generate synchronisation from a pattern of desynchronised spikes. The transition from desynchronous spikes to synchronous bursts activities, induced by varying the synaptic coupling, emerges in a hysteretic loop due to a bistable regime where normal (desynchronous) or abnormal (synchronous) regimes exist. We show that, for parameters within the bistable region, a square current pulse can trigger the abnormal synchronous regime, a process we claim to reproduce features of an epileptic seizure. We can also suppress it, as well. Suppression can be achieved through a current with small amplitude applying on less than 10\% of neurons. Therefore, our results demonstrate that electrical stimulation not only can trigger synchronous behaviours, but also can be an effective treatment for epileptic seizures induced in a bistable regime.