Comparison of Two Dose Regimens of Misoprostol for Cervical Ripening and Labor Induction

Objective : To compare the safety and efficacy of two dose regimens of intravaginally administered misoprostol () for cervical ripening and labor induction. Methods : One hundred patients with unfavorable cervix (including PROM) for labor induction were randomly assigned to group A and group B. Group A patients received 25 of vaginal misoprostol every 4 hours with maximum of 6 doses and group B patients received 25, 50 , 100 , 100 of misoprostol every 4 hours with maximum of 4 doses. Misoprostol was inserted to the posterior vaginal fornix. Successful induction was defined when Bishop score was increased to greater than 9 or regular uterine contractions were developed. The rates of successful induction, vaginal delivery, mean time from induction to delivery, drug side effects, and neonatal outcomes were compared. Results : The average interval from start of induction to vaginal delivery was shorter in group B (780.1313.0 minutes) than group A (1108.9485.9 minutes) (p