Changes in serum and striatal free amino acids after Venezuelan equine encephalomyelitis virus infection.

Abstract The infection with the Venezuelan equine encephalomyelitis virus produced a significant increase in the concentration of alanine, arginine, asparagine, glutamine, isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, tyrosine, and valine in the striatum of rats. On the contrary, the concentrations of aspartate, GABA, glutamate, and taurine were reduced. Arginine, aspartate, glycine, methionine, phenylalanine, taurine, and tyrosine concentrations were increased in the serum of infected rats. However, the modifications in the content of free amino acids in the striatum and serum of rats that survived the infection were qualitatively and quantitatively different from those detected during the acute phase of the infection.