Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury

Enrico Velardi,Jennifer J. Tsai,Stefan Radtke,Kirsten Cooper,Kimon V. Argyropoulos,Shieh Jae-Hung,Lauren F. Young,Amina Lazrak,Odette M. Smith,Sophie Lieberman,Fabiana M Kreines,Yusuke Shono,Tobias Wertheimer,Robert R. Jenq,Alan M. Hanash,Prema Narayan,Zhenmin Lei,Malcolm A.S. Moore,Hans Peter Kiem,Marcel R.M. van den Brink,Jarrod A. Dudakov

Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury

2018

A luteinizing hormone–releasing hormone antagonist, used clinically for sex-steroid inhibition, promotes quiescence of hematopoietic stem cells and thereby promotes hematopoietic recovery and survival of lethally irradiated mice.

Keywords:

Immunology
Stem cell
Cancer research
Medicine
Haematopoiesis
Luteinizing hormone
Hormone antagonist

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