Effect of peptide YY on gastric, pancreatic, and biliary function in humans

Abstract The effect of peptide YY (PYY) on gastric and pancreatico-biliary secretion was studied in humans. Peptide YY was infused into groups of 6 healthy volunteers at doses of 0.59, 0.20, and 0.064 pmol · kg −1 · min −1 . The two higher doses caused a significant suppression of gastric acid and pepsin output during background stimulation with pentagastrin. The middle dose of PYY (0.20 pmol · kg −1 · min −1 ) that increased plasma PYY levels by 27 ± 2 pM caused a 90% ± 18% (mean ± SEM; p −1 · min −1 ) had no significant influence on duodenal juice volume, output of bicarbonate, trypsin, or bilirubin during low dose stimulation with secretin (0.25 pmol · kg −1 · min −1 ) and cholecystokinin-8 (0.15 pmol · kg −1 · min −1 ). Thus PYY concentrations in the circulation similar to those seen after the ingestion of food cause a marked reduction in gastric secretion. This peptide should therefore be considered as one of the possible candidates for the classical enterogastrone.