Are there prognostic parameters for predicting the success of regional chemotherapy in nonresectable liver metastases of colorectal cancer

: When compared with systemic therapy, hepatic arterial chemotherapy significantly increases the response rate for hepatic metastases from colorectal carcinomas. However, only 2 studies showed a significant prolongation of survival. In our study on 54 patients tumor related characteristics and the response to regional chemotherapy were correlated to the success of the treatment. In a linear discriminant analysis the response to regional chemotherapy was the main prognostic factor for the 1-year survival, rate, followed by positive lymph nodes in the Lig. hepatoduodenale. The other pretherapeutic factors such as liver involvement and CEA rate were of less importance.