Expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type
2018
Objective. To investigate the expression of
TIM-3 and LAG-3 in extranodal NK/T cell lymphoma,
nasal type (ENKTL), and evaluate the clinical and
prognostic significance of TIM-3 and LAG-3 in
ENKTL.
Methods. A total of 61 human paraffin-embedded
specimens including 41 ENKTL and 20 rhinitis were
involved. We performed immunohistochemistry to detect
the expression of TIM-3 and LAG-3. We analyzed
correlation between expression of TIM-3 and LAG-3
and clinicopathological features of ENKTL.
Results. TIM-3 was positively expressed in 95
(39/41) ENKTL compared with 55% (11/20) in rhinitis,
LAG-3 was positively expressed in 95 (39/41) ENKTL
compared with 45% (9/20) in rhinitis. A positive
correlation was found between TIM-3 and LAG-3. TIM3
and LAG-3 had no significant correlation with ENKTL
patients’ age, gender, international prognostic index (IPI)
score, B symptoms, LDH level, Ann Arbor stage and
treatment regimens. High expression of TIM-3, high IPI
score, elevated LDH level and late Ann Arbor stage
were shown to be correlated with worse progression free
survival (PFS). A multivariate COX regression model
show that TIM-3 high expression rate was an
independent prognostic factor for ENKTL patients’ PFS.
Conclusions. Our findings indicate that TIM-3 might
be a promising predictive indicator for the ENKTL
patients.
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