B symptoms refer to systemic symptoms of fever, night sweats, and weight loss which can be associated with both Hodgkin's lymphoma and non-Hodgkin's lymphoma. The presence or absence of B symptoms has prognostic significance and is reflected in the staging of these lymphomas.aggressive: Sézary disease B symptoms refer to systemic symptoms of fever, night sweats, and weight loss which can be associated with both Hodgkin's lymphoma and non-Hodgkin's lymphoma. The presence or absence of B symptoms has prognostic significance and is reflected in the staging of these lymphomas. B symptoms are so called because Ann Arbor staging of lymphomas includes both a number (I–IV) and a letter (A or B). 'A' indicates the absence of systemic symptoms, while 'B' indicates their presence.