Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca2+-Activated K+ Channels in Glioma Cells

Poh Shiow Yeh,Shyh-Jong Wu,Te-Yu Hung,Yan Ming Huang,Chia Wei Hsu,Chun-I Sze,Yi Jung Hsieh,Chin Wei Huang,Sheng-Nan Wu

Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca2+-Activated K+ Channels in Glioma Cells

2016

Poh Shiow Yeh
Shyh-Jong Wu
Te-Yu Hung
Yan Ming Huang
Chia Wei Hsu
Chun-I Sze
Yi Jung Hsieh
Chin Wei Huang
Sheng-Nan Wu

Background: Temozolomide (TMZ), an oral alkylator of the imidazotetrazine family, is used to treat glioma. Whether this drug has any ionic effects in glioma cells

Keywords:

Membrane potential
Temozolomide
DNA damage
Biochemistry
Glioma
Cancer research
RNA interference
Ionomycin
Patch clamp
Dacarbazine
Biology
k channels
glioma cell

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