Ionomycin

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes.It is also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. These cytokines are important in the inflammatory response. Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes.It is also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. These cytokines are important in the inflammatory response. Commercially, ionomycin can be obtained as a free acid, or as a Ca2+ salt.