Antisperm antibodies induce polyspermy by promoting adherence of human sperm to zona-free hamster eggs

In the present study, small limited populations of antibody-labelled and antibody-free spermatozoa from fertile donors were observed serially by phase contrast, epifluorescence and scanning electron microscopy following their adherence to the oolemma of zona-free hamster eggs. These observations indicate that ASAs promote polyspermic fertilization of zona-free hamster eggs primarily through their enhancement of sperm-oolemmal binding