Spermatozoon

A spermatozoon (pronounced /ˌspɜːrmætəˈzoʊən/, alternate spelling spermatozoön; plural spermatozoa; from Ancient Greek: σπέρμα 'seed' and Ancient Greek: ζῷον 'living being') is a motile sperm cell, or moving form of the haploid cell that is the male gamete. A spermatozoon joins an ovum to form a zygote. (A zygote is a single cell, with a complete set of chromosomes, that normally develops into an embryo.)Electron micrograph of human spermatozoa magnified 3140 times.Sperm cells in the urine sample of a 45-year-old male patient who is being followed with the diagnosis of benign prostate hyperplasia.Another image from the same urine sample as with the image on the left. A spermatozoon (pronounced /ˌspɜːrmætəˈzoʊən/, alternate spelling spermatozoön; plural spermatozoa; from Ancient Greek: σπέρμα 'seed' and Ancient Greek: ζῷον 'living being') is a motile sperm cell, or moving form of the haploid cell that is the male gamete. A spermatozoon joins an ovum to form a zygote. (A zygote is a single cell, with a complete set of chromosomes, that normally develops into an embryo.) Sperm cells contribute approximately half of the nuclear genetic information to the diploid offspring (excluding, in most cases, mitochondrial DNA). In mammals, the sex of the offspring is determined by the sperm cell: a spermatozoon bearing a X chromosome will lead to a female (XX) offspring, while one bearing a Y chromosome will lead to a male (XY) offspring. Sperm cells were first observed in Antonie van Leeuwenhoek's laboratory in 1677. The human sperm cell is the reproductive cell in males and will only survive in warm environments; once it leaves the male body the sperm's survival likelihood is reduced and it may die, thereby decreasing the total sperm quality. Sperm cells come in two types, 'female' and 'male'. Sperm cells that give rise to female (XX) offspring after fertilization differ in that they carry an X-chromosome, while sperm cells that give rise to male (XY) offspring carry a Y-chromosome. A human sperm cell consists of a flat, disc shaped head 5.1 µm by 3.1 µm and a tail 50 µm long. The tail flagellates, which propels the sperm cell (at about 1–3 mm/minute in humans) by whipping in an elliptical cone. Sperm have an olfactory guidance mechanism, and after reaching the Fallopian tubes, must undergo a period of capacitation before penetration of the ovum. Head: It has a compact nucleus with only chromatic substance and is surrounded by only a thin rim of cytoplasm. Above the nucleus lies a cap-like structure called the acrosome, formed by modification of the Golgi body, which secretes the enzyme spermlysin (hyaluronidase, corona-penetrating enzyme, zona eyesin, or aerosin.) On the surface of the head lies a decapacitating substance which is removed before fertilisation. Neck: It is the smallest part (0.03 ×10−6 m), and has a proximal and distal centriole. The proximal centriole enters into the egg during fertilisation and starts the first cleavage division of the egg, which has no centriole. The distal centriole gives rise to the axial filament which forms the tail and has a (9+2) arrangement. A transitory membrane called the Manchette lies in the middle piece. Middle piece: It has 10–14 spirals of mitochondria surrounding the axial filament in the cytoplasm. It provides motility, and hence is called the powerhouse of the sperm. It also has a ring centriole (annulus) that form a diffusion barrier between the middle piece and the principal piece and serve as a stabilizing structure for tail rigidity. Tail: It is the longest part (50×10−6 m), having an axial filament surrounded by cytoplasm and plasma membrane, but at the posterior end the axial filament is naked. Semen has an alkaline nature and the spermatozoa do not reach full motility (hypermotility) until they reach the vagina, where the alkaline pH is neutralized by acidic vaginal fluids. This gradual process takes 20–30 minutes. During this period, fibrinogen from the seminal vesicles forms a clot, securing and protecting the sperm. Just as they become hypermotile, fibrinolysin from the prostate gland dissolves the clot, allowing the sperm to progress optimally.