SIRT1 and adult stem cell senescence

stem cells differentiate into a variety of somatic cells which perform particular functions,in order to maintain integrity of specific tissues and organs during their lifespan.Studies have shown that senescence,which contributes to aging and the weakness under stress,occurs in adult stem cells.Sirtuins 1(SIRT1) is a NAD+-dependent deacetylase in mammalian cells.Activated SIRT1 may have anti-senescence effects on somatic cells,as well as in adult stem cells through balancing stem cell quiescence and proliferation,maintaining self-renewal capacity,ameliorating age-related decline in stem cell function and diminishing differentiation bias.Molecular mechanisms underlying SIRT1 anti-senescence ability still require to be investigated.