Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.
1999
Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl-2-thiazolylthio)-5-methanesulfonamido-3H-isobenzofuran-1-one 14 was found to be the optimal compound in the series with superior in vitro and in vivo activities.
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